{"id":376,"date":"2017-11-21T17:46:23","date_gmt":"2017-11-21T16:46:23","guid":{"rendered":"https:\/\/www.purkynuvfond.cz\/?page_id=376\/"},"modified":"2020-03-24T10:43:43","modified_gmt":"2020-03-24T09:43:43","slug":"rozhovor-s-pharm-dr-jitkou-palich-fucikovou-ph-d","status":"publish","type":"page","link":"https:\/\/www.purkynuvfond.cz\/vitezne-prace\/rozhovor-s-pharm-dr-jitkou-palich-fucikovou-ph-d\/","title":{"rendered":"Ro\u010dn\u00edk 2016"},"content":{"rendered":"

Rozhovor s MUDr. Dagmar My\u0161\u00edkovou<\/strong><\/span><\/p>\n

V\u00edt\u011bzka Ocen\u011bn\u00ed publikace v\u00a0\u010dasopise s\u00a0nejvy\u0161\u0161\u00edm impact\u00a0factorem\u00a0za rok 2016 v\u00a0kategorii chirurgick\u00e9 obory<\/strong><\/span><\/p>\n

Ocen\u011bn\u00ed\u00a0Purky\u0148ova\u00a0nada\u010dn\u00edho fondu jste z\u00edskala za nejlep\u0161\u00ed pr\u00e1ci v\u00a0kategorii chirurgick\u00e9 obory. Mohla byste pros\u00edm obsah Va\u0161\u00ed pr\u00e1ce kr\u00e1tce\"\"\u00a0objasnit?
\n<\/strong>Tato pr\u00e1ce vznikla na z\u00e1klad\u011b n\u011bkolikalet\u00e9 spolupr\u00e1ce na\u0161\u00ed kliniky, tedy III. chirurgick\u00e9 kliniky 1. LF UK a\u00a0FNM\u00a0s\u00a0Imunologickou klinikou 2. LF UK a\u00a0FNM, v\u00a0neposledn\u00ed \u0159ad\u011b se spole\u010dnost\u00ed\u00a0Sotio\u00a0a.s. Stru\u010dn\u011b \u0159e\u010deno na\u0161e studie hodnotila specifickou\u00a0protin\u00e1dorovou\u00a0imunitn\u00ed odpov\u011b\u010f proti antigen\u016fm\u00a0nemalobun\u011b\u010dn\u00e9ho\u00a0karcinomu plic. Bylo zji\u0161t\u011bno, \u017ee tato odpov\u011b\u010f je v\u00fdznamn\u011b modifikov\u00e1na\u00a0abusem\u00a0cigaretov\u00e9ho kou\u0159e. Vy\u0161\u0161\u00ed frekvence protil\u00e1tek proti n\u00e1dorov\u00fdm antigen\u016fm byly prok\u00e1z\u00e1ny ve skupin\u011b ku\u0159\u00e1k\u016f a exku\u0159\u00e1k\u016f s\u00a0karcinomem plic oproti skupin\u011b neku\u0159\u00e1k\u016f. Dle dostupn\u00fdch informac\u00ed, byla tato zji\u0161t\u011bn\u00ed publikov\u00e1na v\u016fbec poprv\u00e9.<\/span><\/p>\n

M\u011bla jste mo\u017enost studovat \u010di pracovat v\u00a0zahrani\u010d\u00ed?
\n<\/strong>Absolvovala jsem p\u0159edev\u0161\u00edm krat\u0161\u00ed pobyty na mezin\u00e1rodn\u00edch konferenc\u00edch v\u00a0Amsterdamu,\u00a0\u017denev\u011b\u00a0a Barcelon\u011b. V\u0161echny byly spojen\u00e9 s\u00a0prezentac\u00ed v\u00fdsledk\u016f na\u0161\u00ed pr\u00e1ce zam\u011b\u0159en\u00e9 na problematiku karcinomu plic. Ka\u017ed\u00e1 konference byla inspirativn\u00ed a p\u0159inesla mi \u0159adu podn\u011bt\u016f k\u00a0dal\u0161\u00ed pr\u00e1ci a v\u00fdzkumu, n\u011bkter\u00e9 z\u00a0nich ji\u017e aplikujeme v\u00a0na\u0161em nov\u00e9m projektu. A\u010dkoli jsou konference dle m\u00e9ho n\u00e1zoru velmi p\u0159\u00ednosn\u00e9, nyn\u00ed bych se r\u00e1da zam\u011b\u0159ila na zlep\u0161en\u00ed vlastn\u00ed chirurgick\u00e9 techniky t\u0159eba i formou zahrani\u010dn\u00ed st\u00e1\u017ee.<\/p>\n

V\u00a0sou\u010dasnosti p\u016fsob\u00edte ve Fakultn\u00ed nemocnici\u00a0Motol. M\u016f\u017eete n\u00e1m pros\u00edm p\u0159ibl\u00ed\u017eit, na \u010dem aktu\u00e1ln\u011b pracujte?
\n<\/strong>Velmi si v\u00e1\u017e\u00edm toho, \u017ee mohu pracovat na III. chirurgick\u00e9 klinice, kde jsem m\u011bla mo\u017enost poznat chirurgii v\u00a0cel\u00e9 jej\u00ed \u0161\u00ed\u0159i d\u00edky zku\u0161en\u00fdm koleg\u016fm a u\u010dit se od nejlep\u0161\u00edch v oboru, jak\u00fdmi bezesporu jsou pan profesor\u00a0Pafko\u00a0a pan profesor\u00a0Lischke.
\nR\u00e1da bych se v\u00edce v\u011bnovala hrudn\u00ed chirurgii a z\u00e1rove\u0148 pokra\u010dovala ve v\u00fdzkumu u pacient\u016f s\u00a0karcinomem plic. N\u00e1\u0161 v\u00fdzkumn\u00fd t\u00fdm se v\u00a0sou\u010dasnosti rozr\u016fst\u00e1 a m\u00e1me v pl\u00e1nu \u0161ir\u0161\u00ed v\u00edceoborovou spolupr\u00e1ci. V\u00a0budoucnu by se na projektu m\u011bl \u00fa\u010dastnit chirurg, imunolog, patolog a n\u00e1dorov\u00fd biolog s\u00a0c\u00edlem identifikace nez\u00e1visl\u00fdch prognostick\u00fdch faktor\u016f u karcinomu plic.
\nV\u00a0m\u00e9 klinick\u00e9 praxi m\u011b nejv\u00edce t\u011b\u0161\u00ed, kdy\u017e m\u016f\u017eeme pomoci, co\u017e nemus\u00ed b\u00fdt pravidlem, hlavn\u011b u pokro\u010dil\u00fdch onkologick\u00fdch onemocn\u011bn\u00ed.\u00a0\u010casto\u00a0n\u00e1s pacienti \u017e\u00e1daj\u00ed o druh\u00fd n\u00e1zor, kdy\u017e na jin\u00e9m pracovi\u0161ti uzav\u0159eli jejich p\u0159\u00edpad jako\u00a0inoperabiln\u00ed. D\u011bl\u00e1 mi radost, pokud se poda\u0159\u00ed i takov\u00e9 pacienty \u00fasp\u011b\u0161n\u011b odoperovat na na\u0161em pracovi\u0161ti a zlep\u0161it tak jejich progn\u00f3zu.<\/p>\n

Va\u0161e profese je bezpochyby n\u00e1ro\u010dn\u00e1 a vy\u017eaduje spoustu \u010dasu. Jak tr\u00e1v\u00edte voln\u00e9 chv\u00edle a jak relaxujete?
\n<\/strong>Relaxuji v\u011bt\u0161inou aktivn\u011b p\u0159edev\u0161\u00edm sportem, v\u00a0l\u00e9t\u011b se v\u011bnuji triatlonu a lezen\u00ed, v\u00a0zim\u011b\u00a0snowboardingu. Letos jsem m\u011bla radost, kdy\u017e se mi poda\u0159ilo dokon\u010dit dva del\u0161\u00ed\u00a0triatlony\u00a0typu \u201ehalf\u00a0ironman\u201c, atmosf\u00e9ra z\u00e1vod\u016f byla skv\u011bl\u00e1 a moc jsem si je u\u017eila i p\u0159es fyzick\u00e9 vy\u010derp\u00e1n\u00ed i nep\u0159\u00edze\u0148 po\u010das\u00ed.
\nSrdcovou z\u00e1le\u017eitost\u00ed je pro m\u011b alpine snowboarding, nem\u00e1m moc \u010dasu tr\u00e9novat, ale \u00fa\u010dastn\u00edm se t\u00e9m\u011b\u0159 v\u0161ech z\u00e1vod\u016f \u010desk\u00e9ho poh\u00e1ru, kde se\u00a0mi da\u0159ilo bodovat. Mezi z\u00e1vodn\u00edky m\u00e1m skv\u011bl\u00e9 p\u0159\u00e1tele, samotn\u00e9 z\u00e1vody jsou v\u017edy i spole\u010denskou ud\u00e1lost\u00ed. Pobyt na hor\u00e1ch mi dod\u00e1v\u00e1 energii v zim\u011b i \u00a0l\u00e9t\u011b.
\nDal\u0161\u00ed voln\u00e9 chv\u00edle v\u011bnuji \u010d\u00e1ste\u010dn\u011b studiu a \u010detb\u011b r\u016fzn\u00fdch \u017e\u00e1nr\u016f beletrie. V\u011bt\u0161inou m\u00e1m roze\u010dten\u00fdch najednou n\u011bkolik knih a vyb\u00edr\u00e1m si mezi nimi dle aktu\u00e1ln\u00ed n\u00e1lady.<\/p>\n

 <\/p>\n

Rozhovor s Pharm.Dr. Jitkou Palich Fu\u010d\u00edkovou, Ph.D.<\/strong><\/span><\/p>\n

V\u00edt\u011bzka Ocen\u011bn\u00ed publikace v\u00a0\u010dasopise s\u00a0nejvy\u0161\u0161\u00edm impact factorem za rok 2016 v\u00a0kategorii teoretick\u00e9 obory<\/strong><\/span><\/p>\n

Ocen\u011bn\u00ed Purky\u0148ova nada\u010dn\u00edho fondu jste z\u00edskala za nejlep\u0161\u00ed pr\u00e1ci v\u00a0kategorii teoretick\u00e9 obory. Mohla byste pros\u00edm obsah Va\u0161\u00ed pr\u00e1ce kr\"\"\u00e1tce objasnit?<\/strong>
\nVe sv\u00e9 v\u00fdzkumn\u00e9 pr\u00e1ci se v\u011bnuji roli imunitn\u00edho syst\u00e9mu v\u00a0boji proti n\u00e1dorov\u00fdm onemocn\u011bn\u00edm. Sou\u010dasn\u00e9 poznatky v\u00a0oblasti n\u00e1dorov\u00e9 biologie ukazuj\u00ed, \u017ee imunitn\u00ed syst\u00e9m je\u00a0schopen rozpoznat a \u00fa\u010dinn\u011b eliminovat n\u00e1dorov\u00e9 bu\u0148ky d\u0159\u00edve ne\u017e se projev\u00ed jako z\u00e1va\u017en\u00e9 onemocn\u011bn\u00ed. Imunogenn\u00ed smrt n\u00e1dorov\u00fdch bun\u011bk na rozd\u00edl od fyziologick\u00e9 apopt\u00f3zy vede ke\u00a0stimulaci imunitn\u00edho syst\u00e9mu pomoc\u00ed molekul asociovan\u00fdch se stresov\u00fdmi podm\u00ednkami. Kl\u00ed\u010dov\u00fdm p\u0159edstavitelem t\u011bchto molekul je kalretikulin, jeho\u017e v\u00fdznam v\u00a0aktivaci imunitn\u00ed odpov\u011bdi byl pops\u00e1n pomoc\u00ed in vitro studi\u00ed a my\u0161\u00edch model\u016f. V\u00a0minul\u00e9m roce jsme publikovaly v\u00fdsledky na\u0161ich studi\u00ed v\u00a0\u010dasopise Blood a Cancer Research, kter\u00e9 dokumentuj\u00ed roli kalretikulinu in vivo v\u00a0l\u00e9\u010db\u011b pacient\u016f s karcinomem plic a akutn\u00ed myeloidn\u00ed leuk\u00e9mi\u00ed. P\u0159\u00edtomnost kalretikulinu na povrchu n\u00e1dorov\u00fdch bun\u011bk pacient\u016f je asociov\u00e1na s\u00a0aktivac\u00ed specifick\u00e9 protin\u00e1dorov\u00e9 imunitn\u00ed odpov\u011bdi a napom\u00e1h\u00e1 identifikovat skupinu pacient\u016f se signifikantn\u011b lep\u0161\u00ed progn\u00f3zou onemocn\u011bn\u00ed. V\u00a0oblasti imunogenn\u00ed bun\u011b\u010dn\u00e9 smrti spolupracujeme s\u00a0francouzskou skupinou profesorky Catherine Fridman, kter\u00e1 je p\u0159edn\u00ed odbornic\u00ed v\u00a0oblasti n\u00e1dorov\u00e9 imunologie a profesorem Guido Kroemerem, kter\u00fd je objevitelem konceptu imunogenn\u00ed bun\u011b\u010dn\u00e9 smrti. Spole\u010dn\u011b jsme identifikovali kalretikulin jako st\u011b\u017eejn\u00ed biomarker u pacient\u016f s\u00a0karcinomem plic.<\/p>\n

M\u011bla jste mo\u017enost studovat \u010di pracovat v\u00a0zahrani\u010d\u00ed?\u00a0<\/strong>
\nV\u00a0r\u00e1mci sv\u00e9 v\u00fdzkumn\u00e9 pr\u00e1ce jsem absolvovala n\u011bkolik zahrani\u010dn\u00edch st\u00e1\u017e\u00ed. Diplomovou pr\u00e1ci jsem vypracovala v\u00a0laborato\u0159i INSERM v\u00a0Pa\u0159\u00ed\u017ei, kde se dlouhodob\u011b zab\u00fdvaj\u00ed rol\u00ed imunitn\u00edho syst\u00e9mu v\u00a0l\u00e9\u010db\u011b hematologick\u00fdch malignit. Tato zku\u0161enost byla st\u011b\u017eejn\u00ed pro v\u00fdb\u011br doktorsk\u00e9ho studia na 2. LF UK, kde jsem se v\u011bnovala problematice imunogenn\u00ed bun\u011b\u010dn\u00e9 smrti n\u00e1dorov\u00fdch bun\u011bk. B\u011bhem doktorsk\u00e9ho studia jsem pracovala 9 m\u011bs\u00edc\u016f v\u00a0laborato\u0159i Ludwig Institute for Cancer Research v\u00a0Austr\u00e1lii. Zde jsem se v\u011bnovala zejm\u00e9na roli imunitn\u00edho syst\u00e9mu v l\u00e9\u010db\u011b malign\u00edho melanomu. Posledn\u00ed zahrani\u010dn\u00ed st\u00e1\u017e jsem absolvovala v\u00a0r\u00e1mci postdoktorsk\u00e9ho studia v\u00a0Pa\u0159\u00ed\u017ei v\u00a0laborato\u0159i prof. Catherine Fridman a prof. Guido Kroemera. Spole\u010dn\u011b jsme identifikovali kalretikulin jako prognostick\u00fd biomarker pacient\u016f s\u00a0nemalobun\u011b\u010dn\u00fdm karcinomem plic. V\u0161echny absolvovan\u00e9 st\u00e1\u017ee byly velk\u00fdm p\u0159\u00ednosem, jak pro profesion\u00e1ln\u00ed tak osobn\u00ed \u017eivot. Mimo jedine\u010dn\u00e9 zku\u0161enosti a znalosti jsem z\u00edskala \u0159adu kontakt\u016f a p\u0159\u00e1tel, s\u00a0kter\u00fdmi nad\u00e1le spolupracujeme na dal\u0161\u00edch v\u00fdzkumn\u00fdch projektech.<\/p>\n

V\u00a0sou\u010dasnosti p\u016fsob\u00edte ve Fakultn\u00ed nemocnici Motol a biotechnologick\u00e9 spole\u010dnosti Sotio. M\u016f\u017eete n\u00e1m pros\u00edm p\u0159ibl\u00ed\u017eit, na \u010dem aktu\u00e1ln\u011b pracujte?<\/strong>
\nV\u00a0sou\u010dasn\u00e9 chv\u00edli se sna\u017e\u00edme roz\u0161\u00ed\u0159it na\u0161e znalosti o roli kalretikulinu v\u00a0l\u00e9\u010db\u011b pacient\u016f s\u00a0r\u016fzn\u00fdmi n\u00e1dorov\u00fdmi malignitami v\u00a0r\u00e1mci prob\u00edhaj\u00edc\u00ed multicentrick\u00e9 v\u011bdeck\u00e9 studie. Sou\u010dasn\u011b bychom r\u00e1di popsali i p\u0159\u00edpadn\u00fd prognostick\u00fd a prediktivn\u00ed v\u00fdznam dal\u0161\u00edch molekul asociovan\u00fdch s\u00a0imunogenn\u00ed bun\u011b\u010dnou smrt\u00ed v\u00a0biologii n\u00e1dorov\u00fdch malignit a detailn\u011b objasnili roli t\u011bchto molekul v aktivaci imunitn\u00ed odpov\u011bdi.<\/p>\n

Va\u0161e profese je bezpochyby n\u00e1ro\u010dn\u00e1 a vy\u017eaduje spoustu \u010dasu. Jak tr\u00e1v\u00edte voln\u00e9 chv\u00edle a jak relaxujete?
\n<\/strong>M\u00e1m dv\u011b mal\u00e9 d\u011bti, tak\u017ee se sna\u017e\u00edm voln\u00fd \u010das tr\u00e1vit s\u00a0rodinou. M\u00fdm velk\u00fdm kon\u00ed\u010dkem je cestov\u00e1n\u00ed, nav\u0161t\u00edvila jsem v\u00edce ne\u017e 30 zem\u00ed, s\u00a0man\u017eelem r\u00e1di chod\u00edme po hor\u00e1ch.
\n<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Rozhovor s MUDr. Dagmar My\u0161\u00edkovou V\u00edt\u011bzka Ocen\u011bn\u00ed publikace v\u00a0\u010dasopise s\u00a0nejvy\u0161\u0161\u00edm impact\u00a0factorem\u00a0za rok 2016 v\u00a0kategorii chirurgick\u00e9 obory Ocen\u011bn\u00ed\u00a0Purky\u0148ova\u00a0nada\u010dn\u00edho fondu jste z\u00edskala za nejlep\u0161\u00ed pr\u00e1ci v\u00a0kategorii chirurgick\u00e9 obory. Mohla byste pros\u00edm obsah Va\u0161\u00ed pr\u00e1ce kr\u00e1tce\u00a0objasnit? Tato pr\u00e1ce vznikla na z\u00e1klad\u011b n\u011bkolikalet\u00e9 spolupr\u00e1ce na\u0161\u00ed kliniky, tedy III. chirurgick\u00e9 kliniky 1. LF UK a\u00a0FNM\u00a0s\u00a0Imunologickou klinikou 2. LF UK a\u00a0FNM, […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":49,"menu_order":63,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-376","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.purkynuvfond.cz\/api\/wp\/v2\/pages\/376","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.purkynuvfond.cz\/api\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.purkynuvfond.cz\/api\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.purkynuvfond.cz\/api\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.purkynuvfond.cz\/api\/wp\/v2\/comments?post=376"}],"version-history":[{"count":7,"href":"https:\/\/www.purkynuvfond.cz\/api\/wp\/v2\/pages\/376\/revisions"}],"predecessor-version":[{"id":1720,"href":"https:\/\/www.purkynuvfond.cz\/api\/wp\/v2\/pages\/376\/revisions\/1720"}],"up":[{"embeddable":true,"href":"https:\/\/www.purkynuvfond.cz\/api\/wp\/v2\/pages\/49"}],"wp:attachment":[{"href":"https:\/\/www.purkynuvfond.cz\/api\/wp\/v2\/media?parent=376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}